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Papaverine is an opium alkaloid used primarily in the treatment of visceral spasm, vasospasm (especially those involving the heart and the brain), and occasionally in the treatment of erectile dysfunction.[11] While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the other opium alkaloids.
Uses
Approved
Papaverine is approved to treat spasms of the gastointestinal tract, bile ducts and ureter and for use as a cerebral and coronary vasodilator[12] in subarachnoid hemorrhage (combined with balloon angioplasty)[13] and coronary artery bypass surgery.[14]
Side effects
Frequent side effects of papaverine treatment include polymorphic ventricular tachycardia, constipation, interference with sulphobromophthalein retention test (used to determine hepatic function[15]), increased transaminase levels, increased alkaline phosphatase levels, hyperbilirubinemia, somnolence, and vertigo.[16]
Rare side effects include flushing of the face, hyperhidrosis (excessive sweating), cutaneous eruption, arterial hypotension, tachycardia, lack of appetite, jaundice, eosinophilia, thrombopenia, mixed hepatitis, headache, allergic reaction, chronic active hepatitis,[17] and paradoxical aggravation of cerebral vasospasm.[18]
Formulations and Tradenames
Papaverine is available as a conjugate of hydrochloride, codecarboxylate, adenylate, and teprosylate.[19] It was also once available as a salt of hydrobromide, camsylate, cromesilate, nicotinate, and phenylglycolate. The hydrochloride salt is available for intramuscular, intravenous, rectal and oral administration.[20] The teprosylate is available in intravenous, intramuscular, and orally administered formulations.[21] The codecarboxylate is available in oral form, only,[22] as is the adenylate.[23]
The codecarboxylate is sold under the name Albatran®,[24] the adenylate as Dicertan®,[25] and the hydrochloride salt is sold variously as Artegodan® (Germany), Cardioverina® (countries outside Europe and the United States), Dispamil® (countries outside Europe and the United States), Opdensit® (Germany), Panergon® (Germany), Paverina Houde® (Italy, Belgium), Pavacap (United States), Pavadyl® (United States), Papaverin-Hamelin® (Germany), Paveron® (Germany), Spasmo-Nit® (Germany),[26] Cardiospan®, Papaversan®, Cepaverin®, Cerespan®, Drapavel®, Forpaven®, Papalease®, Pavatest®, Paverolan®, Therapav® (France[27]), Vasospan®, Cerebid®, Delapav®, Dilaves®, Durapav®, Dynovas®, Optenyl®, Pameion®, Papacon®, Pavabid®, Pavacen®, Pavakey®, Pavased®, Pavnell®, Alapav®, Myobid®, Vasal®, Pamelon®, Pavadel®, Pavagen®, Ro-Papav®, Vaso-Pav®, Papanerin-hcl®, Qua bid®, Papital T.R.®, Paptial T.R.®, Pap-Kaps-150®.[28]
End Notes
- ^ "SID 544606 -- PubChem Substance Summary." Accessed 25 September 2005. National Center for Biotechnology Information.
- ^ "Papaverine Material Safety Data Sheet." Accessed 25 September 2005.
- ^ see SID 5446606, 2005.
- ^ see SID 5446606, 2005.
- ^ Unknown (2005) PAPAVERINE, Molécule(s) de base : PAPAVERINE [online] Biam. Available from: http://www.biam2.org/www/Sub3015.html Accessed on 25 September 2005. (French)
- ^ see PAPAVERINE, 2000.
- ^ see PAPAVERINE, 2000.
- ^ see PAPAVERINE, 2000.
- ^ Unknown (2005) Who should not take papaverine?, papaverine Consumer Drug Information [online] Cerner Multum, Inc. Available from: http://www.drugs.com/MTM/papaverine.html Accessed on 26 September 2005.
- ^ Unknown (2005) PAPAVERINE CHLORHYDRATE, Molécule(s) de base : PAPAVERINE [online] Biam. Available from: http://www.biam2.org/www/Sub65.html Accessed on 25 September 2005. (French)
- ^ see PAPAVERINE, 2000.
- ^ see PAPAVERINE, 2000.
- ^ Liu, James K.; Couldwell, William T (2005). Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. Neurocritical Care 2 (2): 124-32. PMID 16159054 Fulltext options List of Library Holdings
- ^ Takeuchi K, Sakamoto S, Nagayoshi Y, Nishizawa H, Matsubara J (2004). Reactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery 26 (5): 956-9. PMID 15519189 Fulltext options List of Library Holdings
- ^ "SID 149219 -- PubChem Substance Summary." Accessed 26 September 2005. National Center for Biotechnology Information.
- ^ see PAPAVERINE, 2000.
- ^ see PAPAVERINE, 2000.
- ^ Clyde BL, Firlik AD, Kaufmann AM, Spearman MP, Yonas H (1996). Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report. Journal of Neurosurgery 84 (4): 690-5.
- ^ "Molécule de base : PAPAVERINE." Accessed 26 September 2005. Biam.
- ^ see PAPAVERINE CHLORHYDRATE, 1999.
- ^ Unknown (2005) PAPAVERINE TEPROSILATE, Molécule(s) de base : PAPAVERINE [online] Biam. Available from: http://www.biam2.org/www/Sub70.html Accessed on 26 September 2005. (French)
- ^ Unknown (2005) PAPAVERINE CODECARBOXYLATE, Molécule(s) de base : PAPAVERINE [online] Biam. Available from: http://www.biam2.org/www/Sub1293.html Accessed on 26 September 2005. (French)
- ^ Unknown (2005) PAPAVERINE ADENYLATE, Molécule(s) de base : PAPAVERINE [online] Biam. Available from: http://www.biam2.org/www/Sub1295.html Accessed on 26 September 2005. (French)
- ^ "SID 660773 PubChem Substance Summary." Accessed 25 September 2005. National Center for Biotechnology Information.
- ^ "SID 660767 -- PubChem Substance Summary." Accessed 25 September 2005. National Center for Biotechnology Information.
- ^ see PAPAVERINE CHLORHYDRATE, 1999.
- ^ "THERAPAV (PRODUIT PUR) - Détail." Accessed 26 September 2005. CSST - Service du répertoire toxicologique. (French)
- ^ "SID 660767 -- PubChem Substance Summary - Depositor-Supplied Synonyms: All." Accessed 26 September 2005. National Center for Biotechnology Information.
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